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No More Heroes 2: Desperate Struggle (ノーモア★ヒーローズ 2: デスパレート・ストラグル, Nōmoa★hīrōzu 2: Desuparēto sutoraguru) is an action-adventure hack and slash video game developed for the Wii video game system. It is the sequel to No More Heroes. It was directed by Suda51, developed by Grasshopper Manufacture, published by Ubisoft and Rising Star Games, and was released on January 26, 2010 in North America, May 25, 2010 in Australia, May 28, 2010 in Europe and October 21, 2010 in Japan.

The story of No More Heroes 2 is told with normal cutscenes following Travis' journey, interspersed with scenes of a woman at a peep show dictating the story's events to an unknown observer.

Three years have passed since Travis Touchdown became the top assassin in the United Assassins Association (UAA) and walked away (what happened to him throughout said years is never explained). Now, he returns to Santa Destroy and fights Skelter Helter, who seeks revenge on Travis for killing his older brother Helter Skelter prior to the first game. After winning the battle, he meets Sylvia Christel again, who informs him he is now ranked 51st. The nearly-dead Skelter Helter interrupts them and warns Travis that he and his co-conspirators will still have their revenge.

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