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Resident Evil 5, known in Japan as Biohazard 5 (バイオハザード5, Baiohazādo 5), is a survival horror third-person shooter video game developed and published by Capcom. The fifth major installment in the Resident Evil series, the game was released for the PlayStation 3 and Xbox 360 consoles in March 2009 and for Microsoft Windows in September of that year. Resident Evil 5 was re-released for PlayStation 4 and Xbox One In June 28, 2016. Resident Evil 5's plot involves an investigation by Chris Redfield and Sheva Alomar of a terrorist threat in Kijuju, a fictional region of Africa. Chris soon learns that he must confront his past in the form of an old enemy, Albert Wesker.

The game was announced in 2005, the same year predecessor Resident Evil 4 was released. Several staff members from the original Resident Evil worked on Resident Evil 5. Motion capture was used for the game's cutscenes, and it was the first video game to use a virtual camera system. Resident Evil 5's gameplay was similar to that of the previous installment, and producer Jun Takeuchi said that themes from the original game were used. Resident Evil 5 had a mostly positive reception, although the game was criticised for problems with its controls. Outselling its predecessor, Resident Evil 5 became the franchise's best-selling individual game. A sequel, Resident Evil 6, was released in 2012.

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